Dr. Sonia Anand, AllerGen Principal Investigator and Professor of Medicine at McMaster University, and a team of maternal/child health researchers from across Canada have recently received a $2 million grant to investigate the role of maternal and infant nutrition on … Continued
On Thursday, June 27, 2013, AllerGen Research Leader, Dr. Malcolm Sears, spoke with Kathleen Petty, the host of CBC Radio’s Ontario Today about the Canadian Healthy Infant Longitudinal Development (CHILD) Study. Dr. Sears discussed the benefits of studying the interplay … Continued
Buchholz V, Bridgman SL, Nielsen CC, Gascon M, Tun HM, Simons E, Turvey SE, et al. Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy. mSystems. 2023 DOI: https://doi.org/10.1128/msystems.01190-22.
Bruce CY, Shanmuganathan M, Azab SM, Simons E, Mandhane P, Turvey SE, Subbarao P, et al. The Relationship Between Diet, Gut Microbiota, and Serum Metabolome of South Asian Infants at 1 Year. J Nutr. 2023 Feb;153(2):470-482. doi: 10.1016/j.tjnut.2022.12.016. Epub 2022 Dec 27. PMID: 36894240.
Gutierrez MW, Mercer EM, Moossavi S, Laforest-Lapointe I, Reyna ME, Becker AB, Simons E, et al. Maturational patterns of the infant gut mycobiome are associated with early-life body mass index. Cell Reports Medicine (2023), https://doi.org/10.1016/j.xcrm.2023.100928
Vinther JL, Cadman T, Avraam D, Ekstrøm CT, I. A. Sørensen T, Elhakeem A, Santos AC, et al. Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies. PLoS Med (2023) 20(1): e1004036. https://doi.org/10.1371/journal.pmed.1004036
Dai DLY, Petersen C, Hoskinson C, Del Bel KL, Becker AB, Moraes TJ, Mandhane PJ, et al. Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk. Med (2022), https://doi.org/10.1016/j.medj.2022.12.002
Dahr YE, Perquier F, Moloney M, De Grace RD, Woo G, Carvalho D, Addario N,, et al. Ecological Momentary Assessment with REDCap: Methods, Feasibility, and User Behaviour in a Parent and Child Study. PsyArXiv; 2022. DOI: 10.31234/osf.io/cmkt2.
Parks J, McCandless L, Dharma C, Brook J, Turvey SE, Mandhane P, Becker AB, et al. Association of use of cleaning products with respiratory health in a Canadian birth cohort. CMAJ. 2020 Feb 18;192(7):E154-E161. doi: 10.1503/cmaj.190819. PMID: 32071106; PMCID: PMC7030878.
Parks J, McLean KE, McCandless L, de Souza RJ, Brook JR, Scott J, Turvey SE, et al. Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning. J Expo Sci Environ Epidemiol. 2022 Jan;32(1):112-123. doi: 10.1038/s41370-021-00350-4. Epub 2021 Jun 26. PMID: 34175887; PMCID: PMC8770125.
Sbihi H, Simmons KE, Sears MR, Moraes TJ, Becker AB, Mandhane PJ, Subbarao P, et al. Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy. Pediatr Allergy Immunol. 2022 Jan;33(1):e13658. doi: 10.1111/pai.13658. Epub 2021 Sep 16. PMID: 34467574.
Safavi S, Dai R, Breton VL, Emmerson MN, Kowalik K, Lu Z, Lou W, et al. Lung clearance index predicts persistence of preschool wheeze. Pediatr Allergy Immunol. 2022 Jan;33(1):e13713. doi: 10.1111/pai.13713. Epub 2021 Dec 14. PMID: 34875116.
Dai R, Miliku K, Gaddipati S, Choi J, Ambalavanan A, Tran MM, Reyna M, et al. Wheeze trajectories: Determinants and outcomes in the CHILD Cohort Study. J Allergy Clin Immunol. 2022 Jun;149(6):2153-2165. doi: 10.1016/j.jaci.2021.10.039. Epub 2021 Dec 30. PMID: 34974064.
Akhabir L, Stringer R, Desai D, Mandhane PJ, Azad MB, Moraes TJ, Subbarao P, et al. DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study. BMC Genomics. 2022 Mar 19;23(1):221. doi: 10.1186/s12864-022-08451-6. PMID: 35305575; PMCID: PMC8933946.
Lee-Sarwar KA, Chen YC, Chen YY, Kozyrskyj AL, Mandhane PJ, Turvey SE, Subbarao P, et al. The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes. Allergy. 2022 Sep 15. doi: 10.1111/all.15516. Epub ahead of print. PMID: 36107703.
Reyna ME, Dai R, Tran MM, Breton V, Medeleanu M, Lou WYW, Foong RE, Emmerson M, et al. Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma. JAMA Netw Open. 2022 Oct 3;5(10):e2234714. doi: 10.1001/jamanetworkopen.2022.34714. PMID: 36201211; PMCID: PMC9539714.
Rodriguez N, Tessier CA, Mandhane PJ, Pei J, Simons E, Moraes TJ, Turvey SE, et al. Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment. Front Pediatr. 2022 Sep 6;10:734428. doi: 10.3389/fped.2022.734428. PMID: 36389362; PMCID: PMC9648178.
Dekker PM, Azad MB, Boeren S, Mandhane PJ, Moraes TJ, Simons E, Subbarao P, Turvey SE, et al. The human milk proteome and allergy of mother and child: Exploring associations with protein abundances and protein network connectivity. Front Immunol. 2022 Oct 13;13:977470. doi: 10.3389/fimmu.2022.977470. PMID: 36311719; PMCID: PMC9613325.
Bedard P, Winsor GL, Garlock ES, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, et al. From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants. Children (Basel). 2022 Sep 27;9(10):1475. doi: 10.3390/children9101475. PMID: 36291411; PMCID: PMC9600175.
Ezeugwu VE, Adamko D, van Eeden C, Dubeau A, Turvey SE, Moraes TJ, Simons E, et al. Development of a predictive algorithm to identify pre-school children at risk for behavior changes associated with sleep-related breathing disorders. Sleep Med. 2022 Sep 24;100:472-478. doi: 10.1016/j.sleep.2022.09.015. Epub ahead of print. PMID: 36252416.
Tun MH, Chari R, Kaul P, Mamede FV, Paulden M, Lefebvre DL, Turvey SE, et al. Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study. PLoS One. 2022 Oct 6;17(10):e0268229. doi: 10.1371/journal.pone.0268229. PMID: 36201407; PMCID: PMC9536615.
Chen YY, Zhao X, Moeder W, Tun HM, Simons E, Mandhane PJ, Moraes TJ, Turvey SE, et al. Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota. Microorganisms. 2021 Aug 31;9(9):1847. doi: 10.3390/microorganisms9091847. PMID: 34576741; PMCID: PMC8467529.
Obiakor CV, Parks J, Takaro TK, Tun HM, Morales-Lizcano N, Azad MB, Mandhane PJ, et al. Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants. Antibiotics (Basel). 2022 Jul 21;11(7):981. doi: 10.3390/antibiotics11070981. PMID: 35884235; PMCID: PMC9311587.
Reyna-Vargas ME, Parmar A, Lefebvre DL, Azad MB, Becker AB, Turvey SE, Moraes TJ, et al. Longitudinal Associations Between Sleep Habits, Screen Time and Overweight, Obesity in Preschool Children. Nat Sci Sleep. 2022 Jul 5;14:1237-1247. doi: 10.2147/NSS.S363211. PMID: 35818483; PMCID: PMC9270899.
Bridgman SL, Malmuthuge N, Mandal R, Field CJ, Haqq AM, Mandhane PJ, Moraes TJ, et al. Childhood body mass index and associations with infant gut metabolites and secretory IgA: findings from a prospective cohort study. Int J Obes (Lond). 2022 Jul 15. doi: 10.1038/s41366-022-01183-3. Epub ahead of print. PMID: 35840772.
Reyna ME, Petersen C, Dai DLY, Dai R, Becker AB, Azad MB, Miliku K, et al. Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life. Int J Obes (2022). https://doi.org/10.1038/s41366-022-01117-z.
Dai R, Miliku K, Gaddipati S, Choi J, Ambala A, Tran MM, Reyna M, et al. Wheeze Trajectories: Determinants and Outcomes in the CHILD Cohort Study. J Allergy Clin Immunol. 2021 Dec 30:S0091-6749(21)02747-0. doi: 10.1016/j.jaci.2021.10.039. Epub ahead of print. PMID: 34974064.
Safavi S, Dai R, Breton VL, Emmerson MN, Kowalik K, Lu Z, Lou W, et al. Lung Clearance Index predicts persistence of preschool wheeze. Pediatr Allergy Immunol. 2021 Dec 7. doi: 10.1111/pai.13713. Epub ahead of print. PMID: 34875116.
Moossavi S, Atakora F, Fehr K, Khafipour E. Biological observations in microbiota analysis are robust to the choice of 16S rRNA gene sequencing processing algorithm: case study on human milk microbiota. BMC Microbiol 20, 290 (2020). https://doi.org/10.1186/s12866-020-01949-7.
Azad MB, Dharma C, Simons E, Tran M, Reyna ME, Dai R, et al. Reduced peanut sensitization with maternal peanut consumption and early peanut introduction while breastfeeding. J Dev Orig Health Dis. 2021 Oct;12(5):811-818. doi: 10.1017/S2040174420001129. Epub 2020 Dec 9.
Loewen K, Moraes TJ, Turvey SE, Mandhane PJ, Sears MR, Subbarao P, et al. Prenatal egg consumption and infant sensitization and allergy to egg, peanut, and cow’s milk in the CHILD Cohort. J Allergy Clin Immunol Pract. 2021 May;9(5):2109-2112.e2. doi: 10.1016/j.jaip.2020.11.061. Epub 2020 Dec 13.
Simard M, Madore AM, Girard S, Waserman S, Duan Q, Subbarao P, et al. Polygenic Risk Score for Atopic Dermatitis in the Canadian Population. Journal of Allergy and Clinical Immunology. 2021 Jan;147(1):406-409. doi: 10.1016/j.jaci.2020.04.057. Epub 2020 May 19.
van Eeden C, Tamana SK, Narang I, Hammam N, Chikuma J, Lefebvre DL, et al. Development and Validation of SDBeasy Score as a Predictor of Behavioral Outcomes in Childhood. Am J Respir Crit Care Med. 2021 Mar 15;203(6):718-725. doi: 10.1164/rccm.202002-0363OC.
Vu K, Lou W, Tun HM, Konya TB, Morales-Lizcano N, Chari RS, et al. From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome. Gastroenterology. 2021 Jan;160(1):128-144.e10. doi: 10.1053/j.gastro.2020.08.053. Epub 2020 Sep 16.
Navaranjan G, Jantunen LM, Diamond ML, Harris SA, Bernstein S, Scott JA, Takaro TK, et al. Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma. Environ. Sci. Technol. Lett. 2021 8 (7), 531-537. DOI: 10.1021/acs.estlett.1c00210
Shanmuganathan M, Kroezen Z, Gill B, Azab S, de Souza RJ, Teo KK, Atkinson S, et al. The maternal serum metabolome by multisegment injection-capillary electrophoresis-mass spectrometry: a high-throughput platform and standardized data workflow for large-scale epidemiological studies. Nat Protoc. 2021 Apr;16(4):1966-1994. doi: 10.1038/s41596-020-00475-0.
de Souza RJ, Zulyniak MA, Stearns JC, Wahi G, Teo K, Gupta M, Sears MR, et al. The influence of maternal and infant nutrition on cardiometabolic traits: novel findings and future research directions from four Canadian birth cohort studies. Proc Nutr Soc. 2019 Aug;78(3):351-361. doi: 10.1017/S0029665119000612. Epub 2019 May 29. PMID: 31140389.
Chooniedass R, Tarrant M, Turner S, Lok Fan HS, Del Buono K, Masina S, Becker AB, et al. Factors associated with breastfeeding initiation and continuation in Canadian-born and non-Canadian-born women: a multi-centre study. Public Health Nutr. 2021 Dec 3:1-31. doi: 10.1017/S1368980021004699. Epub ahead of print. PMID: 34859767.
Chehab R, Fehr K, Moossavi S, Moraes T, Mandhane P, de Souza R, Turvey S, et al. Maternal Prenatal Supplement Intake, but Not Dietary Patterns, Is Associated With Human Milk Microbiota Composition in the CHILD Cohort Study. Curr. Dev. Nutr., 5:2, June 2021, p 1154, https://doi.org/10.1093/cdn/nzab054_009.
Rodd C, Feely A, Becker AB, Moraes TJ, Subbarao P, Mandhane PJ, Turvey SE, et al. World Health Organization growth standards: How do Canadian children measure up? Paediatr Child Health, 26:5, August 2021, pp e208–e214, https://doi.org/10.1093/pch/pxaa053.
Turvey SE, Lee TY, Sears MR, Becker AB, Mandhane PJ, Moraes TJ, Subbarao P, et al. Development of a conceptual model of childhood asthma to inform asthma prevention policies. BMJ Open Resp Res. 2021 doi: 10.1136/bmjresp-2021-000881.
van Eeden C, Tamana SK, Narang I, Hammam N, Chikuma J, Lefebvre DL, Azad MB, et al. Development and Validation of SDBeasy Score as a Predictor of Behavioral Outcomes in Childhood. Am J Respir Crit Care Med. 2021 Mar 15;203(6):718-725. doi: 10.1164/rccm.202002-0363OC. PMID: 32898424.
Sbihi H, Simmons KE, Sears MR, Moraes TJ, Becker AB, Mandhane PJ, Subbarao P, et al. Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy. Pediatr. Allergy Immunol. 01 Sep 2021 https://doi.org/10.1111/pai.13658.
Miliku K, Moraes TJ, Becker AB, Mandhane PJ, Sears MR, Turvey SE, Subbarao P, et al. Breastfeeding in the First Days of Life Is Associated With Lower Blood Pressure at 3 Years of Age. J Amer Heart Assn. 21 Jul 2021 https://doi.org/10.1161/JAHA.120.019067.
Tamana SK, Tun HM, Konya T, Chari RS, Field CJ, Guttman DS, Becker AB, et al. Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment. Gut Microbes. 2021 Jan-Dec;13(1):1-17. doi: 10.1080/19490976.2021.1930875.
Parks J, McLean KE, McCandless L, de Souza RJ, Brook JR, Scott J, Turvey SE, et al. Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning. J Expo Sci Environ Epidemiol. 2021 Jun 26. doi: 10.1038/s41370-021-00350-4.
Boutin RCT, Sbihi H, McLaughlin RJ, Hahn AS, Konwar KM, Loo RS, et al. Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes. mBio (2021 June 1), he0339620. doi: 10.1128/mBio.03396-20.
Petersen C, Dai DLY, Boutin RCT, Sbihi H, Sears MR, Moraes TJ, et al. A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization. Cell Reports Medicine (2021), https://doi.org/10.1016/j.xcrm.2021.100260
Ezeugwu VE, Mandhane PJ, Hammam N, Brook JR, Tamana SK, Hunter S, et al. https://journals.humankinetics.com/view/journals/jpah/18/5/article-p571.xml. Journal of Physical Activity and Health 18.5 (2021): 571-579.
Boutin RCT, Petersen C, Woodward SE, Serapio-Palacios A, Bozorgmehr T, Loo R, et al. Bacterial-fungal interactions in the neonatal gut influence asthma outcomes later in life. eLife 2021;10:e67740 DOI: 10.7554/eLife.67740.
Tun HM, Peng Y, Chen B, Konya TB, Morales-Lizcano NP, Chari R, et al. Ethnicity associations with food sensitization are mediated by gut microbiota development in the first year of life. Gastroenterology. 2021 Mar 16:S0016-5085(21)00523-0. doi: 10.1053/j.gastro.2021.03.016.
Chow A, Dharma C, Chen E, Mandhane PJ, Turvey SE, Elliott SJ, et al. Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions. Am J Public Health. 2019 Jun;109(S3):S197-S204
Moossavi S, Fehr K, Khafipour E, Subbarao P, Azad MB. Repeatability and reproducibility assessment in a large-scale population-based microbiota study: case study on human milk microbiota. Microbiome 9, 41 (2021). https://doi.org/10.1186/s40168-020-00998-4.
Moossavi S, Fehr K, Derakhshani H, Sbihi H, Robertson B, Bode L, et al. Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study. BMC Microbiol 20, 146 (2020). https://doi.org/10.1186/s12866-020-01829-0.
Rodd C, Feely A, Becker AB, Moraes TJ, Subbarao P, Mandhane PJ, et al. World Health Organization growth standards: How do Canadian children measure up? Paediatrics & Child Health, pxaa053, https://doi.org/10.1093/pch/pxaa053.
Lu Z, Dai R, Kowalik K, Dubeau A, Lefebvre DL, Balkovec S, et al. Newly developed multiple-breath washout reference equations from the CHILD Cohort Study: implications of poorly fitting equations. ERJ Open Res. 2021 Jan 25;7(1):00301-2020. doi: 10.1183/23120541.00301-2020.
Navaranjan G, Diamond ML, Harris SA, Jantunen LM, Bernstein S, Scott JA, et al. Early life exposure to phthalates and the development of childhood asthma among Canadian children. Environ Res. 2021 Mar 7;197:110981. doi: 10.1016/j.envres.2021.110981.
Miliku K, Richelle J, Becker AB, Simons E, Moraes TJ, Turvey SE, et al. Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions. Pediatr Allergy Immunol. 2021 Mar 12. doi: 10.1111/pai.13500.
Laforest-Lapointe I, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, et al. Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index. Gut Microbes. 2021 Jan-Dec;13(1):1-15.
Cait A, Cardenas E, Dimitriu PA, Amenyogbe N, Dai D, Cait J, et al. Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization. J Allergy Clin Immunol. 2019 Dec;144(6):1638-1647.e3.
Chan D, Becker AB, Moraes TJ, Mandhane PJ, Sears MR, Turvey SE, et al. Sex-specific association of human milk hormones and asthma in the CHILD cohort. Pediatric Allergy and Immunology. 2020 Jan 18.
Akhabir L, Rosenberg E, Tworek D, Heroux D, Balhara J, McNagny KM, et al. Cord Blood Hemopoietic Cell Receptor Expression is Associated with Early Life Atopic Risk and Lung Function. Allergy. 2020 Jan 22.
Parks J, McCandless L, Dharma C, Brook J, Turvey SE, Mandhane P, et al. Association of use of cleaning products with respiratory health in a Canadian birth cohort. Canadian Medical Association Journal. 2020 Feb 18;192(7):E154-E161.
Boutin RCT, Sbihi H, Dsouza M, Malhotra R, Petersen C, Dai D, et al. Mining the infant gut microbiota for therapeutic targets against atopic disease. Allergy. 2020 Feb 22.
Kang LJ, Vu KN, Koleva PT, Field CJ, Chow A, Azad MB, et al. Maternal psychological distress before birth influences gut immunity in mid‐infancy Clin Exp Allergy. 2020 Feb. 50(2):178-188.
Patrick DM, Sbihi H, Dai DLY, Al Mamun A, Rasali D, Rose C, et al. Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies. Lancet Respiratory Medicine. 2020 Mar 24. pii: S2213-2600(20)30052-7.
Azad MB, Archibald A, Tomczyk MM, Head A, Cheung KG, de Souza RJ, et al. Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells. International Journal of Obesesity (Lond). 2020 May 4. doi: 10.1038/s41366-020-0575-x.
Zulyniak MA, de Souza RJ, Shaikh M, Ramasundarahettige C, Tam K, Williams N, et al. Ethnic differences in maternal diet in pregnancy and infant eczema. PLoS One. 2020 May 14;15(5):e0232170.
Moossavi S, Fehr K, Derakhshani H, Sbihi H, Robertson B, Bode L, et ak. Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study. BMC Microbiology. 2020 Jun 5;20(1):146.
Hammam N, Sadeghi D, Carson V, Tamana SK, Ezeugwu VE, Chikuma J, et al. The relationship between machine-learning derived sleep parameters and behaviour problems in 3- and 5-year old children; results from the CHILD Cohort study. Sleep. 2020 Jun 12:zsaa117.
Nielsen CC, Gascon M, Osornio-Vargas AR, Shier C, Guttman DS, Becker AB, et al. Natural environments in the urban context and gut microbiota in infants. Environmental International. 2020 Sep;142:105881.
Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, et al. Breastmilk Feeding Practices Are Associated with the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: the CHILD Cohort Study. Cell Host Microbe. 2020 Aug 12;28(2):285-297.e4.
Vézina K, Mariasine J, Young R, Reyna M, Lu Z, Subbarao P, et al. Cardiorespiratory Monitoring Data during Sleep in One-year-old Healthy Canadian Infants. Ann Am Thorac Soc. 2020 Jul 17.
Drall KM, Field CJ, Haqq AM, de Souza RJ, Tun HM, Morales-Lizcano NP, et al. Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections. Gut Microbes. 2020 Nov 9;12(1):1799734.
de Souza RJ, Shanmuganathan M, Lamri A, Atkinson SA, Becker A, Desai D, et al. Maternal Diet and the Serum Metabolome in Pregnancy: Robust Dietary Biomarkers Generalizable to a Multiethnic Birth Cohort. Curr Dev Nutr. 2020 Sep 2;4(10):nzaa144.
Drall KM, Tun HM, Morales-Lizcano NP, Konya TB, Guttman DS, Field CJ, et al. Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3–4 Months of Age. Front. Immunol. 10:2866. doi: 10.3389/fimmu.2019.02866.
Sbihi H, Jones MJ, MacIsaac JL, Brauer M, Allen RW, Sears MR, et al. Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization. J Allergy Clin Immunol. 2019 Dec;144(6):1729-1731.e5.
Simons E, Balshaw R, Lefebvre DL, Dai D, Turvey SE, Moraes TJ, et al. Timing of Introduction, Sensitization and Allergy to Highly-Allergenic Foods at Age 3 Years in a General-Population Canadian Cohort. J Allergy Clin Immunol Pract. (2019), doi: https://doi.org/10.1016/j.jaip.2019.09.039.
Moossavi S, Atakora F, Miliku K, Sepehri S, Robertson B, Duan QL, et al. Integrated analysis of human milk microbiota with oligosaccharides and fatty acids in the CHILD cohort. Front. Nutr. 6:58. doi: 10.3389/fnut.2019.00058.
Miliku K, Duan QL, Moraes TJ, Becker AB, Mandhane PJ, Turvey SE, et al. Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study. Am J Clin Nutr. 2019 Dec 1;110(6):1370-1383.
Chen W, Subbarao P, McGihon RE, Feldman LY, Zhu J, Lou W, et al. Patterns of health care use related to respiratory conditions in early life: A birth cohort study with linked administrative data. Pediatr Pulmonol 2019; Jun 6. doi: 10.1002/ppul.24381.
Carson V, Ezeugwu VE, Tamana SK, Chikuma J, Lefebvre DL, Azad MB, et al. Associations between meeting the Canadian 24-Hour Movement Guidelines for the Early Years and behavioral and emotional problems among 3-year-olds. J Sci Med Sport 2019; Jan 10. pii: S1440-2440(18)31027-2.
Azad MB. Infant feeding and the developmental origins of chronic disease in the CHILD cohort: role of human milk bioactives and gut microbiota. Breastfeeding Medicine. 2019. Vol. 14, No. S1.
Tamana SK, Ezeugwu V, Chikuma J, Lefebvre DL, Azad MB, Moraes TJ, et al. (2019) Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study. PLOS ONE 2019 14(4): e0213995.
Workman CE, Becker AB, Azad MB, Moraes TJ, Mandhane PJ, Turvey SE, et al. Associations between concentrations of perfluoroalkyl substances in human plasma and maternal, infant, and home characteristics in Winnipeg, Canada. Environ Pollut. 2019 Mar 21;249:758-766.
Ho NT, Lee-Sarwar KA, Tun HM, Brown BP, Pannaraj PS, Bender JM, et al. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nature Communications 2018;9:4169.
Bridgman SL, Kozyrskyj AL, Scott JA, Becker AB, Azad MB. Gut microbiota and allergic disease in children. Ann Allergy Asthma Immunol. 2016 Feb;116(2):99-105
Miliku K1, Azad MB. Breastfeeding and the Developmental Origins of Asthma: Current Evidence, Possible Mechanisms, and Future Research Priorities. Nutrients. 2018 Jul 30;10(8)
Moossavi S, Miliku K, Sepehri S, Khafipour E, Azad MB. The Prebiotic and Probiotic Properties of Human Milk: Implications for Infant Immune Development and Pediatric Asthma. Front Pediatr. 2018 Jul 24;6:197
Obiakor CV, Tun HM, Bridgman SL, Arrieta M-C, Kozyrskyj AL. The association between early life antibiotic use and allergic disease in young children: recent insights and their implications. Expert Rev Clin Immunol. 2018 Oct;14(10):841-855
Matenchuk BA, Tamana SK, Lou WYW, Lefebvre DL, Sears MR, Becker AB, et al. Prenatal Depression and Birth Mode Sequentially Mediate Maternal Education’s Influence on Infant Sleep Duration. Sleep Medicine. https://doi.org/10.1016/j.sleep.2019.01.015
Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, et al. Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors. Cell Host Microbe. 2019 Feb 13; 25(2): 324-335. e4. doi: 10.1016/j.chom.2019.01.011.
Graham C, Chooniedass R, Stefura WP, Becker AB, Sears MR, Turvey SE, et al. Innate immunity acquires an anti-inflammatory bias during healthy human pregnancy: opportunities to examine links between early life environment and childhood development of allergic disorders. In: Bochner BS, Creticos PS, eds. Towards precision diagnosis and targeted intervention in allergic disease: 31st Symposium of the Collegium Internationale Allergologicum Proceedings. Pisa: Pacini Giuridica; 2018. p. 21-26.
Dharma C, Lefebvre DL, Tran MM, Lu Z, Lou WYW, Subbarao P, Becker AB, et al. Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment. Paediatr Perinat Epidemiol. 2018 Nov;32(6):556-567. doi: 10.1111/ppe.12525. Epub 2018 Nov 21.
Azad MB, Vehling L, Chan D, Klopp A, Nickel NC, McGavock JM, et al. Infant Feeding and Weight Gain: Separating Breast Milk From Breastfeeding and Formula From Food. Pediatrics. 2018 Oct;142(4). pii: e20181092. doi: 10.1542/peds.2018-1092.
Cusack L, Sbihi H, Larkin A, Chow A, Brook JR, Moraes T, et al. Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study. Int J Health Geogr. 2018 Dec 4;17(1):43. doi: 10.1186/s12942-018-0160-x.
Krzeczkowski JE, Lau A, Fitzpatrick J, Tamana S, Smithson L, de Souza R, et al. Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age. Matern Child Health J. 2019 Jan 2. doi: 10.1007/s10995-018-2691-y.
Tun MH, Tun HM, Mahoney JJ, Konya TB, Guttman DS, Becker AB, et al. Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children. CMAJ. 2018 Sep 17; 190(37): E1097–E1107.
Azad MB, Robertson B, Atakora F, Becker AB, Subbarao P, Moraes TJ, et al. Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices. J Nutr. 2018 Nov 1;148(11):1733-1742. doi: 10.1093/jn/nxy175.
Dharma C, Lefebvre DL, Lu Z, Lou WYW, Becker AB, Mandhane PJ, et al. Risk for Maternal Depressive Symptoms and Perceived Stress by Ethnicities in Canada: From Pregnancy Through the Preschool Years. The Canadian Journal of Psychiatry. 2018;:070674371879219.
Graham C, Chooniedass R, Stefura WP, Lotoski L, Lopez P, Befus AD, et al. Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies. Journal of Translational Medicine [Internet]. 2017Feb;15(1).
Zulyniak MA, de Souza RJ, Shaikh M for the NutriGen Alliance investigators, et al Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance BMJ Open 2017;7:e017753. doi: 10.1136/bmjopen-2017-017753
Bridgman SL, Azad MB, Persaud RR, Chari RS, Becker AB, Sears MR, et al. Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differences. Pediatr Obes. 2018. doi: 10.1111/ijpo.12291. [Epub ahead of print]
Entz R, Rai U, Rycroft J, Chari RS, Kozyrskyj AL. Regional caesarean delivery practices, the maternal-infant microbiome, and risk for asthma. J Obstet Gynecol Canada. 2018. doi: 10.1016/j.jogc.2018.01.025.
Vehling L, Chan D, McGavock J, Becker AB, Subbarao P, Moraes TJ, et al. Exclusive breastfeeding in hospital predicts longer breastfeeding in Canada: Implications for health equity. Birth. 2018;00:1-10. https://doi.org/10.1111/birt.12345.
Kang LJ, Koleva PT, Field CJ, Giesbrechtc GF, Wine E, Becker AB, et al. Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants. Brain Behav Immun 2018;68:123-131.
Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, et al. Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring. JAMA Pediatr. JAMA Pediatrics 2018 172:368-377
Tamana SK, Smithson L, Lau A, Mariasine J, Young R, Chikuma J, et al. Parent-reported symptoms of sleep disordered breathing is associated with increased behavioral problems at 2 years of age: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. Sleep 2018:41
Yasmin F, Tun HM, Konya TB, Guttman DS, Chari RS, Field CJ, et al. Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy. Front. Pediatr. 2017;5:200
Klopp A, Vehling L, Becker AB, Subbarao P, Mandhane PJ, Turvey S, et al. Modes of infant feeding and the risk of childhood asthma: a prospective birth cohort study. J Pediatr 2017 190:192-199.e2
Koleva PT, Tun HM, Konya T, Guttman DS, Becker AB, Mandhane PJ, et al. Sex-specific impact of asthma during pregnancy on infant gut microbiota. Eur Respir J 2017 50(5)
Tran MM, Lefebvre DL, Dharma C, Dai D, Lou WYW, Subbarao P, et al. Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study. J Allergy Clin Immunol 2018;141:601-607
Chan D, Goruk S, Becker A, Subbarao P, Mandhane P, Turvey S, et al. Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life. Int J Obes (Lond) 2018;42:36-43
Graham C, Chooniedass R, Stefura WP, Becker AB, Sears MR, Turvey SE, et al. In vivo immune signatures of healthy human pregnancy: inherently inflammatory or anti-inflammatory?. PLoS One 2017 12:e0177813
Tran MM, Lefebvre DL, Dai D, Dharma C, Subbarao P, Lou W, et al. Timing of food introduction and development of food sensitization in a prospective birthcohort. Pediatr Allergy Immunol 2017;28:471-477
Bridgman SL, Azad MB. Field CJ, Haqq AM, Becker AB, Mandhane PJ, et al. Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations. Front Nutr. 2017 4:11
Stearns JC, Zulyniak MA, de Souza RJ, Campbell NC, Fontes M, Shaikh M, et al. Ethnic and diet-related differences in the healthy infant microbiome. Genome Med 2017;9:32
Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ et al. Exposure to household furry pets influences the gut microbiota of infants at 3–4 months following various birth scenarios. Microbiome 2017;5:40
Stiemsma LT, Turvey SE. Asthma and the microbiome: defining the critical window in early life. Allergy Asthma Clin Immunol 2017;13:3
Azad MB, Vehling L, Lu Z, Dai D, Subbarao P, Becker AB, et al. Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study. Eur Respir 2017;49
de Souza R, Zulyniak M, Desai D, Shaikh M, Campbell N, Lefebvre D, et al. Harmonization of Food-Frequency Questionnaires and Dietary Pattern Analysis in 4 Ethnically Diverse Birth Cohorts. J Nutr 2016;146:2343-2350
Stiemsma L, Arrieta MC, Dimitriu P, Cheng J, Thorson L, Lefebvre D, et al. Shifts in Lachnospira and Clostridium sp. In the 3-month stool microbiome are associated with preschool-age asthma. Clin Sci 2016;130:2199-2207
Subbarao P, Lu Z, Kowalik K, Brown M, Balkovec S, Gustafsson P, et al. Changes in multiple breath washout measures after raised volume rapid thoracoabdominal compression maneuvers in infants. Pediatr Pulmonol 2016;51:183-188
Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL. Gut microbiota diversity and atopic disease: does breastfeeding play a role? J Allergy Clin Immunol 2013; 131: 247-248.
Lu Z, Foong RE, Kowalik K, et al. Ventilation inhomogeneity in infants with recurrent wheezing. Thorax. Published Online First: 15 June 2018. doi: 10.1136/thoraxjnl-2017-211351
Kozyrskyj AL, Tun HM, Bridgman SL. The microbiome and control of weight gain. In: Pediatric Obesity, Contemporary Endocrinology. Freemark MS (ed). Springer International Publishing 2018.
Kozyrskyj AL, Bridgman SL, Tun MH. The impact of birth and postnatal medical interventions on infant gut microbiota. In: Microbiota in health and disease: from pregnancy to childhood. Browne PD, Claassen E, Cabana MD (eds). Wageningen Academic Publishers 2017; ch 4
Lu Z, Foong RE, Kowalik K, Moraes TJ, Dubeau A, Lefebvre D, et al. Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants. Pediatric Pulmonology. 2018. doi: 10.1002/ppul.24063
Miliku K, Robertson B, Sharma AK, Subbarao P, Becker AB, Mandhane PJ, et al. Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study. Allergy. 2018. doi:10.1111/all.13476
Smithson L, Baird T, Tamana SK, Lau A, Mariasine J, Chikuma J, et al. Shorter sleep duration is associated with reduced cognitive development at two years of age. Sleep Medicine. 2018;48:131–9.
Kamal M, Tamana SK, Smithson L, Ding L, Lau A, Chikuma J, et al. Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms. Sleep Medicine. 48:93–100.
Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, et al. Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life. JAMA Pediatr. Published online June 4, 2018. doi:10.1001/jamapediatrics.2018.116
Dharma C, Lefebvre DL, Tran MM, Lou WYW, Subbarao P, Becker AB, et al. Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases. Clin Exp Allergy 2018;48:48–59
Tran MM, Sears MR. Can the atopic march be predicted? Ann Allergy Asthma Immunol 2018; 120:115-19.
Azad MB, Sharma AK, de Souza R, Dolinsky VW, Becker AB, Mandhane PJ, et al. Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index. JAMA Pediatrics 2016;170:662-70.
Bridgman SL, Konya T, Azad MB, Guttman DS, Sears MR, Becker AB, et al. High fecal IgA is associated with reduced Clostridium difficile colonization in infants. Microbes Infect 2016;18:543-9.
Pakpour S, Scott JA, Turvey SE, Brook JR, Takaro TK, Sears MR, et al. Presence of Archaea in the indoor environment and their relationship with housing characteristics. Microb Ecol 2016 72:305-12.
Bolduc FV, Lau A, Rosenfelt CS, Langer S, Wang N, Smithson L, et al. Cognitive enhancement in infants associated with maternal fruit intake during pregnancy: results from a birth cohort study with validation in an animal model. EBioMedicine 2016;8:331-40.
Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, et al. Infant gut immunity: a preliminary study of IgA associations with brreastfeeding. J Developmental Origins Health and Disease 2016;7:68-72.
Kozyrskyj AL Can we predict future allergies from our infant gut microbiota? Expert Rev Respir Med 2015;9:667-670.
Kozyrskyj AL, Kalu R, Koleva PT, Bridgman SL. Fetal programming of overweight through the microbiome: boys are disproportionately affected. J DOHaD 2016;7:25-34.
Arrieta M-C, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, et al. Early infancy microbial and metabolic alterations impact risk of childhood asthma. Science Translational Medicine 2015;7:307 307ra152.
Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, et al. Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study. BJOG 2016;123:983-93.
Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, et al. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax 2015:70:998-1000.
Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, et al. Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy 2015;45:632-43.
Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, et al. The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. J Exposure Science Environ Epidemiol 2015;25:580-592.
Sbihi H, Allen RW, Becker A, Brook JR, Mandhane P, Scott JA, et al. Perinatal exposure to traffic-related air pollution and atopy at 1 year of age in a multi-centre Canadian birth cohort study. Environ Health Perspect 2015;123:902-8.
Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, et al. The Canadian Healthy Infant Longitudinal Development Birth Cohort Study: Biological Samples and Biobanking. Paediatr Perinat Epidemiol. 2015;29:84-92.
Persaud RP, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL et al. Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based cross sectional study. J Matern Fetal Neonatal Med 2015;28:1190-95.
Caulfield T, Burningham S, Joly Y, Master Z, Shabani M, Borry P, et al. A review of the key issues associated with the commercialization of biobanks. J Law Biosciences 2014; 94-110. Doi. 10.1093/jlb/1st004.
Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, et al. Associations between bacterial communities of house dust and infant gut. Environ Res 2014; 131: 25-30.
Maghera A, Kahlke P, Lau A, Zeng Y, Hoskins C, Corbett T, et al. You are how you recruit: a cohort and randomized controlled trial of recruitment strategies. BMC Med Res Methodol 2014;14:111.
Sbihi H, Brook JR, Allen RW, Curran JH, Dell S, Mandhane P, et al. A new exposure metric for traffic-related air pollution? An analysis of determinants of hopanes in settled indoor house dust. Environ Health 2013; 12:48.
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. Can Med Assn J 2013; 185:385-94.
Lum S, Stocks J, Stanojevic S, Wade A, Robinson P, Gustafsson P, et al. Age and height dependence of lung clearance index and functional residual capacity. Eur Respir J 2013; 41: 1371-7.
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol 2013; 9: 15.
Master Z, Ries NM, Caulfield T. Balancing efficiency and the protection of research participants: Canadian allergy/asthma researchers’ perspectives on the ethics review of multi-site health research. J Clinic Res Bioeth 2011; 2: 5.
Arrandale VH, Brauer M, Brook JR, Brunekreef B, Gold DR, London SJ, et al. Exposure assessment in cohort studies of childhood asthma. Environ Health Perspect. 2011; 119: 591-7.
Ries NM, LeGrandeur J, Caulfield T. Handling ethical, legal and social issues in birth cohort studies involving genetic research: responses from studies in six countries. BMC Medical Ethics 2010; 11: 4.
Subbarao P, Mandhane PJ, Sears MR. Asthma: epidemiology, etiology and risk factors. CMAJ 2009; 181: E181-190.
Subbarao P, Becker A, Brook JR, Daley D, Mandhane PJ, Miller GE, et al. Epidemiology of asthma: risk factors for development. Expert Review Clin Immunol 2009; 5: 77-95.
Koleva PT, Kim J-S, Scott JA, Kozyrskyj AL. Microbial programming of health and disease starts during fetal life. Birth Defects Research (Part C) 2015;105:265-277.
