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Author Archives: Marshall Beck

NEW VIDEO: The CHILD Cohort Study and a baby’s microbiome
16 May 2019

NEW VIDEO: The CHILD Cohort Study and a baby’s microbiome

by Marshall Beck | posted in: Announcement | 0

Join us on a journey into the world of a baby’s gut microbiome. Meet some microbial superheroes and learn about how discoveries from the CHILD Cohort Study are helping us to understand allergies, asthma, obesity, and everyday health and wellbeing, … Continued

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CHILD Cohort Study

In this national birth cohort study, researchers are tracking the health of nearly 3,500 Canadian children to find ways to prevent asthma, allergies, obesity and other chronic diseases.

CHILD News

  • Fungi in babies’ guts influence later risk of obesity
  • Preterm babies have lower BMI in infancy but catch up later, study finds
  • Breastfeeding can offset the asthma risk caused by a baby’s exposure to antibiotics
  • CHILD’s Toronto site leader appointed Head of Respiratory Medicine at SickKids
  • Meet the newest members of CHILD’s National Coordinating Centre

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Bruce CY, Shanmuganathan M, Azab SM, Simons E, Mandhane P, Turvey SE, Subbarao P, et al. The Relationship Between Diet, Gut Microbiota, and Serum Metabolome of South Asian Infants at 1 Year. J Nutr. 2023 Feb;153(2):470-482. doi: 10.1016/j.tjnut.2022.12.016. Epub 2022 Dec 27. PMID: 36894240.

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Parks J, McCandless L, Dharma C, Brook J, Turvey SE, Mandhane P, Becker AB, et al. Association of use of cleaning products with respiratory health in a Canadian birth cohort. CMAJ. 2020 Feb 18;192(7):E154-E161. doi: 10.1503/cmaj.190819. PMID: 32071106; PMCID: PMC7030878.

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Parks J, McLean KE, McCandless L, de Souza RJ, Brook JR, Scott J, Turvey SE, et al. Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning. J Expo Sci Environ Epidemiol. 2022 Jan;32(1):112-123. doi: 10.1038/s41370-021-00350-4. Epub 2021 Jun 26. PMID: 34175887; PMCID: PMC8770125.

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Safavi S, Dai R, Breton VL, Emmerson MN, Kowalik K, Lu Z, Lou W, et al. Lung clearance index predicts persistence of preschool wheeze. Pediatr Allergy Immunol. 2022 Jan;33(1):e13713. doi: 10.1111/pai.13713. Epub 2021 Dec 14. PMID: 34875116.

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Lee-Sarwar KA, Chen YC, Chen YY, Kozyrskyj AL, Mandhane PJ, Turvey SE, Subbarao P, et al. The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes. Allergy. 2022 Sep 15. doi: 10.1111/all.15516. Epub ahead of print. PMID: 36107703.

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Reyna ME, Dai R, Tran MM, Breton V, Medeleanu M, Lou WYW, Foong RE, Emmerson M, et al. Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma. JAMA Netw Open. 2022 Oct 3;5(10):e2234714. doi: 10.1001/jamanetworkopen.2022.34714. PMID: 36201211; PMCID: PMC9539714.

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Rodriguez N, Tessier CA, Mandhane PJ, Pei J, Simons E, Moraes TJ, Turvey SE, et al. Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment. Front Pediatr. 2022 Sep 6;10:734428. doi: 10.3389/fped.2022.734428. PMID: 36389362; PMCID: PMC9648178.

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Dekker PM, Azad MB, Boeren S, Mandhane PJ, Moraes TJ, Simons E, Subbarao P, Turvey SE, et al. The human milk proteome and allergy of mother and child: Exploring associations with protein abundances and protein network connectivity. Front Immunol. 2022 Oct 13;13:977470. doi: 10.3389/fimmu.2022.977470. PMID: 36311719; PMCID: PMC9613325.

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Bedard P, Winsor GL, Garlock ES, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, et al. From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants. Children (Basel). 2022 Sep 27;9(10):1475. doi: 10.3390/children9101475. PMID: 36291411; PMCID: PMC9600175.

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Ezeugwu VE, Adamko D, van Eeden C, Dubeau A, Turvey SE, Moraes TJ, Simons E, et al. Development of a predictive algorithm to identify pre-school children at risk for behavior changes associated with sleep-related breathing disorders. Sleep Med. 2022 Sep 24;100:472-478. doi: 10.1016/j.sleep.2022.09.015. Epub ahead of print. PMID: 36252416.

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Tun MH, Chari R, Kaul P, Mamede FV, Paulden M, Lefebvre DL, Turvey SE, et al. Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study. PLoS One. 2022 Oct 6;17(10):e0268229. doi: 10.1371/journal.pone.0268229. PMID: 36201407; PMCID: PMC9536615.

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Chen YY, Zhao X, Moeder W, Tun HM, Simons E, Mandhane PJ, Moraes TJ, Turvey SE, et al. Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota. Microorganisms. 2021 Aug 31;9(9):1847. doi: 10.3390/microorganisms9091847. PMID: 34576741; PMCID: PMC8467529.

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Obiakor CV, Parks J, Takaro TK, Tun HM, Morales-Lizcano N, Azad MB, Mandhane PJ, et al. Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants. Antibiotics (Basel). 2022 Jul 21;11(7):981. doi: 10.3390/antibiotics11070981. PMID: 35884235; PMCID: PMC9311587.

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Reyna-Vargas ME, Parmar A, Lefebvre DL, Azad MB, Becker AB, Turvey SE, Moraes TJ, et al. Longitudinal Associations Between Sleep Habits, Screen Time and Overweight, Obesity in Preschool Children. Nat Sci Sleep. 2022 Jul 5;14:1237-1247. doi: 10.2147/NSS.S363211. PMID: 35818483; PMCID: PMC9270899.

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Bridgman SL, Malmuthuge N, Mandal R, Field CJ, Haqq AM, Mandhane PJ, Moraes TJ, et al. Childhood body mass index and associations with infant gut metabolites and secretory IgA: findings from a prospective cohort study. Int J Obes (Lond). 2022 Jul 15. doi: 10.1038/s41366-022-01183-3. Epub ahead of print. PMID: 35840772.

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Reyna ME, Petersen C, Dai DLY, Dai R, Becker AB, Azad MB, Miliku K, et al. Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life. Int J Obes (2022). https://doi.org/10.1038/s41366-022-01117-z.

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Dai R, Miliku K, Gaddipati S, Choi J, Ambala A, Tran MM, Reyna M, et al. Wheeze Trajectories: Determinants and Outcomes in the CHILD Cohort Study. J Allergy Clin Immunol. 2021 Dec 30:S0091-6749(21)02747-0. doi: 10.1016/j.jaci.2021.10.039. Epub ahead of print. PMID: 34974064.

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Safavi S, Dai R, Breton VL, Emmerson MN, Kowalik K, Lu Z, Lou W, et al. Lung Clearance Index predicts persistence of preschool wheeze. Pediatr Allergy Immunol. 2021 Dec 7. doi: 10.1111/pai.13713. Epub ahead of print. PMID: 34875116.

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Additional criteria for sample release
  • The request must relate to a hypothesis-driven study
  • The study must be deemed by the Executive of CHILD to be fundamentally important to the core objectives of the CHILD study
  • A strong rationale for the need for a longitudinal study design must be evident
  • There must be clarity on the precise samples needed and the volumes required
  • Evidence must be presented that the assays to be employed, and the laboratory to conduct the assays, have high quality control and quality assurance
  • The assays selected must be state-of-the-art, require minimal sample volumes and provide maximum data output; e.g., contrast single parameter analyses versus multiplex assays
  • Information must be provided on funding mechanisms for sample analyses and the study completion
  • Evidence must be provided that ethics approval is available
  • Rationale must be provided as to why the requested samples are required at the current time, rather than after completion of the Study’s 5-year follow-up, with the potential at that time for a more efficient study design; e.g., nested case-controls, etc.
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Azad MB, Sharma AK, de Souza R, Dolinsky VW, Becker AB, Mandhane PJ, et al. Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index. JAMA Pediatrics 2016;170:662-70.

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Bridgman SL, Konya T, Azad MB, Guttman DS, Sears MR, Becker AB, et al. High fecal IgA is associated with reduced Clostridium difficile colonization in infants. Microbes Infect 2016;18:543-9.

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Pakpour S, Scott JA, Turvey SE, Brook JR, Takaro TK, Sears MR, et al. Presence of Archaea in the indoor environment and their relationship with housing characteristics. Microb Ecol 2016 72:305-12.

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Bolduc FV, Lau A, Rosenfelt CS, Langer S, Wang N, Smithson L, et al. Cognitive enhancement in infants associated with maternal fruit intake during pregnancy: results from a birth cohort study with validation in an animal model. EBioMedicine 2016;8:331-40.

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